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IL-4-inhibitor-1 [1332184-63-0]

IL-4-inhibitor-1 [1332184-63-0]

T36527
TargetMol Chemicals
CAS Number1332184-63-0
DownloadMSDS
Product group Chemicals
Estimated Purity98.26%
Molecular Weight321.31
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    IL-4-inhibitor-1 [1332184-63-0]
  • Delivery Days Customer
    4
  • CAS Number
    1332184-63-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    IL-4-inhibitor-1
  • Estimated Purity
    98.26%
  • Molecular Formula
    C18H12FN3O2
  • Molecular Weight
    321.31
  • Scientific Description
    IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 microM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 microM). It is selective for IL-4 over IL-13 (EC50= 18.2 microM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 microM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
  • Shelf life instruction
    3 years
  • SMILES
    Nc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000

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