IL10 Polyclonal Antibody

Reddot Biotech

IL10 Polyclonal Antibody

5

2 mg/ml

IL10

interleukin 10

CSIF; cytokine synthesis inhibitory factor; GVHDS; IL-10; IL10A; interleukin-10; T-cell growth inhibitory factor; TGIF

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappaB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

-20°C

12352203