IL10 Polyclonal Antibody

Reddot Biotech

IL10 Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

Polyclonal

2 mg/ml

Unconjugated

Il10

interleukin 10

CSIF; cytokine synthesis inhibitory factor; If2a; IL-; Il-10; interferon 2a; interleukin-10

Rabbit

IgG

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappaB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Mouse, Rat

-20°C

12352203