IL20RA Antibody / IL-20 receptor subunit alpha

Biorbyt

IL20RA Antibody / IL-20 receptor subunit alpha

10

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P

Research Use Only

Monoclonal

IL20RA/0001

Unconjugated

IL20RA

interleukin 20 receptor subunit alpha

class II cytokine receptor ZCYTOR7; CRF2-8; cytokine receptor family 2 member 8; IL-20R1; IL-20RA; IL-20R-alpha; interleukin 20 receptor alpha subunit; interleukin 20 receptor, alpha; interleukin-20 receptor I; interleukin-20 receptor subunit alpha

Mouse

IgG2

Interleukin-20 receptor subunit alpha

The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-l. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ra and IL-20Rb. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ra and IL-20Rb all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

Human

-20°C

12352203