Bio-Connect

IL4R Polyclonal Antibody

RD266320A
Reddot Biotech
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetIL4R
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    IL4R Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3566
  • Target name
    IL4R
  • Target description
    interleukin 4 receptor
  • Target synonyms
    CD124; IL-4 receptor subunit alpha; IL4R nirs variant 1; IL4RA; IL-4RA; interleukin 13 receptor; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203