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ProductsBack/Imperatorin [482-44-0]
Chemical Structure
Chemical Structure
Chemical Structure

Imperatorin [482-44-0]

Research Use Only
AG-CN2-0084
AdipoGen Life Sciences
CAS Number482-44-0
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Product group Chemicals
Estimated Purity>98%
Molecular Weight270.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Imperatorin [482-44-0]
  • Delivery Days Customer
    10
  • CAS Number
    482-44-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C16H14O4
  • Molecular Weight
    270.3
  • Scientific Description
    Anticancer compound [1, 2, 10, 14]. Apoptosis inducer. Induces DNA fragmentation at the G1/S phase of the cell cycle [1, 2, 14]. HIV-1 replication inhibitor [3]. Anti-inflammatory [4, 9, 11]. Vasodilatation inducer [5]. Increases BMP-2 expression (mRNA) and enhance bone formation [6]. Modulator of SMAD1/5/8, p38, ERK pathways [6]. Exerts anti-hypertrophic effects [7]. Caspase-1 activity inhibitor in vivo and in vitro [8]. Antibacterial and antilisteria compound [12]. L-Type calcium channel blocker [13]. - Chemical. CAS: 482-44-0. Formula: C16H14O4. MW: 270.3. Isolated from Opopanax chironium L. Anticancer compound. Apoptosis inducer. Induces DNA fragmentation at the G1/S phase of the cell cycle. HIV-1 replication inhibitor. Anti-inflammatory. Vasodilatation inducer. Increases BMP-2 expression (mRNA) and enhance bone formation. Modulator of SMAD1/5/8, p38, ERK pathways. Exerts anti-hypertrophic effects. Caspase-1 activity inhibitor in vivo and in vitro. Antibacterial and antilisteria compound. L-Type calcium channel blocker.
  • SMILES
    CC(C)=CCOC1=C2OC(=O)C=CC2=CC2=C1OC=C2
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Imperatorin, a furanocoumarin from Angelica dahurica (Umbelliferae), induces cytochrome c-dependent apoptosis in human promyelocytic leukaemia, HL-60 Cells: H.O. Pae, et al.; Pharmacol. Toxicol. 91, 40 (2002)
  • Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin: G. Appendino, et al.; J. Nat. Prod. 67, 532 (2004)
  • Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway: R. Sancho, et al.; J. Biol. Chem. 279, 37349 (2004)
  • Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT: N. Marquez, et al.; Planta Med. 70, 1016 (2004)
  • Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release: J. Y. He, et al.; Eur. J. Pharmacol. 573, 170 (2007)
  • Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts: C.H.Tang, et al.; Eur. J. Pharmacol. 579, 40 (2008)
  • Furanocoumarins-imperatorin inhibits myocardial hypertrophy both in vitro and in vivo: Y. Zhang, et al.; Fitoterapia 81, 1188 (2010)
  • Distinct effects of imperatorin on allergic rhinitis: imperatorin inhibits caspase-1 activity in vivo and in vitro: H.A. Oh, et al.; J. Pharmacol. Exp. Ther. 339, 72 (2011)
  • Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis: G.J. Huang, et al.; J. Agric. Food Chem. 60, 1673 (2012)
  • Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways: K.W. Luo, et al.; Chemotherapy 57, 449 (2011)