IN-1130

MedChem Express

IN-1130 [868612-83-3]

10

868612-83-3

Research Use Only

99.93

C25H20N6O

420.47

IN-1130 is a highly selective transforming growth factor-beta type I receptor kinase (ALK5) inhibitor with an IC 50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein ( IC 50 =36 nM) and p38alpha mitogen-activated protein kinase ( IC 50 =4.3 microM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis [1] [2] .

O=C(N)C1=CC=CC(CC2=NC(C3=NC(C)=CC=C3)=C(C4=CC=C5N=CC=NC5=C4)N2)=C1

-20°C,2°C to 8°C

12352200