INCB086550

MedChem Express

INCB086550 [2230911-59-6]

10

2230911-59-6

Research Use Only

99.80

C41H39N7O4

693.79

INCB086550 is a potent, oral, small-molecule PD-L1 inhibitor with IC 50s value of 3.1, 4.9 and 1.9 nM for human, cynomolgus, and rat, respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research [1] .

N#CC1=C2C(N=C(C3=C(C(C4=C(C(NC5=NC=CC6=C5N=CC(CN7CC[C@H](C7)O)=C6)=CC=C4)C)=CC=C3)C)O2)=CC(CN8C[C@@H](CC8)C(O)=O)=C1

-20°C,2°C to 8°C

12352200