INCB16562

MedChem Express

INCB16562

9

Research Use Only

C19H11Cl2N5

380.23

INCB16562 is an orally active and selective inhibitor against JAK1/2 markedly selective over JAK3 . INCB16562 potently inhibits interleukin-6 (IL-6)-induced phosphorylation of STAT3. Additionally, INCB16562 inhibits the proliferation and survival of myeloma cells dependent on IL-6 for growth, as well as the IL-6-induced growth of primary bone marrow-derived plasma cells. INCB16562 antagonizes the growth of myeloma xenografts in mice with antitumor activity. INCB16562 is promising for research of multiple myeloma [1] .

ClC1=CC=CC(Cl)=C1C2=NC3=C(N2)C4=C(C=NC=C4)NC5=C3C=CC=N5

12352200