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SYNkinase

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Research Use Only

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1229582-33-5

1311367-27-7

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Bio-Connect Life Sciences

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SYN-1211 | URMC-099 [1229582-33-5] | SYNkinase products available at Bio-Connect

URMC-099 [1229582-33-5]... | SYN-1211 | SYNkinase

URMC-099 [1229582-33-5]

Chemical. CAS: 1229582-33-5. Formula: C27H27N5. MW: 421.5. Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinsons disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable MLK-3 inhibitor with excellent brain exposure in mouse PK models and minimal interference with key human CYP450 enzymes or hERG channels. URMC-099 inhibits multiple kinase pathways, including MLK-3 (14nM) and leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (11nM). - Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinsons disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable MLK-3 inhibitor with excellent brain exposure in mouse PK models and minimal interference with key human CYP450 enzymes or hERG channels. URMC-099 inhibits multiple kinase pathways, including MLK-3 (14nM) and leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (11nM).

SYN-1228 | BIX 02565 [1311367-27-7] | SYNkinase products available at Bio-Connect

BIX 02565 [1311367-27-7]... | SYN-1228 | SYNkinase

BIX02565 [1311367-27-7]

BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1nM. BIX 02565 also has inhibitory effects on LRRK2, RET, CLK2, FLT3 and PDGFR. BIX 02565 can be used in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure. - Chemical. CAS: 1311367-27-7. Formula: C26H30N6O2. MW: 458.6. BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1nM. BIX 02565 also has inhibitory effects on LRRK2, RET, CLK2, FLT3 and PDGFR. BIX 02565 can be used in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.

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