iNOs-IN-5

MedChem Express

iNOs-IN-5

9

Research Use Only

C22H27N3O2

365.47

iNOs-IN-5 (Compound BN-4) is an inhibitor for iNOS with an IC50 of 0.1707 microM, and reduces NO levels in LPS (HT-D1056)-induced RAW264.7 cells. iNOs-IN-5 reduces the hypoxic injury stimulated ROS and lactate dehydrogenase expression, and exhibits anti-necrosis and anti-apoptosis efficacy. iNOs-IN-5 exhibits anti-cerebral ischemia and neuroprotective activities in SD rat models. iNOs-IN-5 is blood-brain barrier penetrable[1].

O=C(OC1CCCC)C2=C1C=CC(NCC3=CC(CNC(C)=N)=CC=C3)=C2

12352200