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Western blot analysis of extracts from Jurkat cells, treated with PMA (1ng/ml, 15mins), using SHIP antibody.
Western blot analysis of extracts from Jurkat cells, treated with PMA (1ng/ml, 15mins), using SHIP antibody.
Western blot analysis of extracts from Jurkat cells, treated with PMA (1ng/ml, 15mins), using SHIP antibody.

INPP5D Antibody

CSB-PA284759
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetINPP5D
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Overview

  • Supplier
    Cusabio
  • Product Name
    INPP5D Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID3635
  • Target name
    INPP5D
  • Target description
    inositol polyphosphate-5-phosphatase D
  • Target synonyms
    hp51CN; inositol polyphosphate-5-phosphatase, 145kD; inositol polyphosphate-5-phosphatase, 145kDa; p150Ship; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SHIP; SHIP1; SHIP-1; signaling inositol polyphosphate 5 phosphatase SIP-145; signaling inositol polyphosphate phosphatase SHIP II; SIP-145
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ92835
  • Protein Name
    Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
  • Scientific Description
    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Chuanlei Wang, Journal of Environmental & Engineering Geophysics, Jun 2006; 11: 123 - 131. Marielle Christiansen, Transportation Science, Feb 2004; 38: 1 - 18. Paul Weimer, AAPG Bulletin, May 1998; 82: 878 - 917. Lewis E. Hunter, Geological Society, Lo
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203