INPP5D Polyclonal Antibody

Reddot Biotech

INPP5D Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

Polyclonal

430 ug/ml

Unconjugated

Inpp5d

inositol polyphosphate-5-phosphatase D

inositol polyphosphate-5-phosphatase, 145 kDa; p150Ship; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; S; s-; SH; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2-containing inositol phosphatase SHIP; SHI; SHIP; SHIP1; SHIP-1; SIP-145; Src homology 2 domain-containing inositol-5-phosphatase; s-SHIP

Rabbit

IgG

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5 phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

Mouse, Rat

-20°C

12352203