Insulin Antibody Cocktail

Biorbyt

Insulin Antibody Cocktail

16

ImmunoHistoChemistry

Immunohistochemistry (FFPE): 0.5-1ug/ml for 30 min at RT IHC-P

Research Use Only

E2-E3 + 2D11-H5 or INS04 + INS05

IgG

This antibody cocktail recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. It enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Specific antibodies can be used as beta-cell and insulinoma markers.

12352203