Insulin antibody [D6C4]

GeneTex

Insulin antibody [D6C4]

9

Clone D6C4 and D3E7 directed to different antigenic determinants. Kd is 8.1 x 10⁻⁸M. This antibody reacts with insulin/proinsulin but does not react with free C-peptide.

ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

D6C4

Unconjugated

INS

insulin

IDDM; IDDM1; IDDM2; ILPR; insulin; IRDN; MODY10; PNDM4; preproinsulin; proinsulin

Mouse

IgG1

Insulin

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Bovine, Human, Mouse, Porcine, Rat

2°C to 8°C

12352203