![Insulin Receptor Alpha (INSR/2277R), CF405S conjugate, 0.1mg/mL [26628-22-8] Insulin Receptor Alpha (INSR/2277R), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2018/10/BNUB2277.jpeg)
Insulin Receptor Alpha (INSR/2277R), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC042277
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Rabbit
TargetINSR
Overview
- SupplierBiotium
- Product NameInsulin Receptor Alpha (INSR/2277R), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDINSR/2277R
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID3643
- Target nameINSR
- Target descriptioninsulin receptor
- Target synonymsCD220; HHF5; insulin receptor; IR
- HostRabbit
- IsotypeIgG
- Protein IDP06213
- Protein NameInsulin receptor
- Scientific DescriptionThe insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Rabbit
- Storage Instruction2°C to 8°C
- UNSPSC12352203