Insulin Receptor beta antibody [CT-1]

GeneTex

Insulin Receptor beta antibody [CT-1]

9

This antibody is specific for the approximately 95 kDa IR and shows no cross-reactivity with insulin like growth factor (IGF) receptors. Phosphorylation of the threonine residue within this sequence (corresponding to threonine 1348) decreases the affinity

ImmunoPrecipitation, ELISA, Purification/Extraction/Isolation

Research Use Only

Monoclonal

CT-1

Unconjugated

INSR

insulin receptor

CD220; HHF5; insulin receptor; IR

Mouse

IgG1

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Human, Mouse, Rat

2°C to 8°C

12352203