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INT-777

T11662L
TargetMol Chemicals
CAS Number1199796-29-6
Product group Chemicals
Molecular Weight450.65
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    INT-777
  • Delivery Days Customer
    9
  • CAS Number
    1199796-29-6
  • Category Supplier
    Chemical
  • Chemical Name
    INT-777
  • Molecular Formula
    C27H46O5
  • Molecular Weight
    450.65
  • Scientific Description
    INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 uM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
  • Shelf life instruction
    3 years
  • SMILES
    O[C@H]1[C@@]2([C@@]([C@]3(C)[C@]([C@H]1CC)(C[C@H](O)CC3)[H])(C[C@H](O)[C@@]4(C)[C@]2(CC[C@@]4([C@@H](C[C@@H](C(O)=O)C)C)[H])[H])[H])[H]
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.
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