InVivoMAb anti-human CD2

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Xu Y, Kolber-Simonds D, Hope JA, et al. The anti-CD2 monoclonal antibody BTI-322 generates unresponsiveness by activation-associated T cell depletion. Clin Exp Immunol. 2004,138(3):476-83.

Snanoudj R, Rouleau M, Bidère N, et al. A role for CD2 antibodies (BTI-322 and its humanized form) in the in vivo elimination of human T lymphocytes infiltrating an allogeneic human skin graft in SCID mice: an Fcgamma receptor-related mechanism involving co-injected human NK cells. Transplantation. 2004,78(1):50-8.

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Nizet Y, Chentoufi AA, Havaux X, et al. Apoptosis of human naive NK cells mediated by a rat IgG2b anti CD2 mAb through a fractricidal ADCC reaction. Immunol Lett. 1999,68(2-3):229-35.

Przepiorka D, Phillips GL, Ratanatharathorn V, et al. A phase II study of BTI-322, a monoclonal anti-CD2 antibody, for treatment of steroid-resistant acute graft-versus-host disease. Blood. 1998,92(11):4066-71.