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InVivoMAb anti-human IL-12 p70
![Research Use Only](static/images/certificates/ruo.jpg)
BE0234
ApplicationsFunctional Assay, Flow Cytometry, ELISA
Product group Antibodies
ReactivityHuman
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-human IL-12 p70
- Delivery Days Customer7
- ApplicationsFunctional Assay, Flow Cytometry, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID20C2
- Concentration4-11 mg/ml
- HostRat
- IsotypeIgG1
- Scientific DescriptionThe 20C2 monoclonal antibody reacts with human interleukin-12 (IL-12), a heterodimeric 70 kDa (p70) cytokine consisting of two covalently linked subunits, 40 kDa (p40) and 35 kDa (p35). IL-12 is secreted by activated monocytes, macrophages, and dendritic cells in response to bacterial pathogens or products such as lipopolysaccharides (LPS). IL-12 is a potent regulator of cell-mediated immune responses and plays a key role in the development of Th1 responses, leading to IFNγ and IL-2 production.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells. Bakdash G et al., 2014 Oct 29, VaccineRead more
- Blood dendritic cell levels associated with impaired IL-12 production and T-cell deficiency in patients with kidney disease: implications for post-transplant viral infections. Chen P et al., 2014 Oct, Transpl IntRead more
- Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells. Hussaarts L et al., 2013 Aug, Immunol Cell BiolRead more
- Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae. Kuri T et al., 2013 Aug, Cell MicrobiolRead more
- Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. Presky DH et al., 1998 Mar 1, J ImmunolRead more