InVivoMAb anti-human IL-12 p70

Name: InVivoMAb anti-human IL-12 p70
SKU: BE0234_B56
Availability: BackOrder

BE0234

ApplicationsFunctional Assay, Flow Cytometry, ELISA

Product group Antibodies

ReactivityHuman

Overview

Supplier
Bio X Cell
Product Name
InVivoMAb anti-human IL-12 p70
Delivery Days Customer
7
Applications
Functional Assay, Flow Cytometry, ELISA
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
20C2
Concentration
4-11 mg/ml
Estimated Purity
>95%
Host
Rat
Isotype
IgG1
Scientific Description
The 20C2 monoclonal antibody reacts with human interleukin-12 (IL-12), a heterodimeric 70 kDa (p70) cytokine consisting of two covalently linked subunits, 40 kDa (p40) and 35 kDa (p35). IL-12 is secreted by activated monocytes, macrophages, and dendritic cells in response to bacterial pathogens or products such as lipopolysaccharides (LPS). IL-12 is a potent regulator of cell-mediated immune responses and plays a key role in the development of Th1 responses, leading to IFNγ and IL-2 production.
Reactivity
Human
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells. Bakdash G et al., 2014 Oct 29, Vaccine
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Blood dendritic cell levels associated with impaired IL-12 production and T-cell deficiency in patients with kidney disease: implications for post-transplant viral infections. Chen P et al., 2014 Oct, Transpl Int
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Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells. Hussaarts L et al., 2013 Aug, Immunol Cell Biol
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Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae. Kuri T et al., 2013 Aug, Cell Microbiol
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Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. Presky DH et al., 1998 Mar 1, J Immunol
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