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InVivoMAb anti-mouse IL-10
BE0049
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse IL-10
- Delivery Days Customer7
- ApplicationsNeutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJES5-2A5
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostRat
- IsotypeIgG1
- Scientific DescriptionThe JES5-2A5 monoclonal antibody reacts with mouse IL-10. IL-10 is a 17-21 kDa cytokine which is primarily produced by monocytes and, to a lesser extent, Th2 cells, mast cells, T regulatory cells, and certain subsets of activated T and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggest that this cytokine is an essential immunoregulator in the intestinal tract. The JES5-2A5 antibody has been shown to neutralize the bioactivity of natural or recombinant IL-10
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Transforming Growth Factor-beta and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals. Komai T et al., 2018, Front ImmunolRead more
- Expanding antigen-specific regulatory networks to treat autoimmunity. Clemente-Casares X et al., 2016 Feb 25, NatureRead more
- IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age. Tsukamoto H et al., 2015 Apr 7, Nat CommunRead more
- Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression. Martinson HA et al., 2015 Apr 15, Int J CancerRead more
- The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells. Vegran F et al., 2014 Aug, Nat ImmunolRead more
- Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance. de Almeida PE et al., 2014 May 30, Nat CommunRead more
- Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation. Yue S et al., 2014 Jun 1, J ImmunolRead more
- TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice. Tai N et al., 2013 Sep 15, J ImmunolRead more
- B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms. Podojil JR et al., 2013 Aug, J AutoimmunRead more
- Modulation of dendritic cell differentiation in the bone marrow mediates sustained immunosuppression after polymicrobial sepsis. Pastille E et al., 2011 Jan 15, J ImmunolRead more
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Product group Antibodies
References
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