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InVivoMAb anti-mouse LPAM-1 (Integrin alpha4beta7)

Research Use Only
BE0034
Bio X Cell
ApplicationsFlow Cytometry, Neutralisation/Blocking
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Product group Antibodies
ReactivityMouse
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-mouse LPAM-1 (Integrin alpha4beta7)
  • Delivery Days Customer
    7
  • Applications
    Flow Cytometry, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    DATK32
  • Concentration
    4-11 mg/ml
  • Host
    Rat
  • Isotype
    IgG2a
  • Scientific Description
    The DATK32 monoclonal antibody reacts with mouse LPAM-1 also known as integrin alpha 4 beta 7. The 130 kDa integrin β7 chain associates with the 150 kDa integrin α4 (CD49d) chain to form LPAM-1, a member of the Ig superfamily. LPAM-1 is expressed by peripheral lymphocytes, small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds VCAM-1 (CD106), MAdCAM-1, and fibronectin and facilitates lymphocyte adhesion and migration to the intestine and associated lymphoid tissues. The DATK32 antibody has been reported to block LPAM-1-mediated cell adhesion in vivo.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis. Duc D et al., 2019 Oct 8, Cell Rep
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  • Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization. Bemark M et al., 2016 Sep 6, Nat Commun
    Read more
  • Regulatory B cells are induced by gut microbiota-driven interleukin-1beta and interleukin-6 production. Rosser EC et al., 2014 Nov, Nat Med
    Read more
  • Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function. Sheridan BS et al., 2014 May 15, Immunity
    Read more
  • Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohns Disease. Lindebo Holm T et al., 2012, Int J Inflam
    Read more