InVivoMAb anti-mouse LPAM-1 (Integrin alpha4beta7)

Name: InVivoMAb anti-mouse LPAM-1 (Integrin alpha4beta7)
SKU: BE0034_B56
Availability: BackOrder

BE0034

ApplicationsFlow Cytometry, Neutralisation/Blocking

Product group Antibodies

ReactivityMouse

Overview

Supplier
Bio X Cell
Product Name
InVivoMAb anti-mouse LPAM-1 (Integrin alpha4beta7)
Delivery Days Customer
7
Applications
Flow Cytometry, Neutralisation/Blocking
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
DATK32
Concentration
4-11 mg/ml
Estimated Purity
>95%
Host
Rat
Isotype
IgG2a
Scientific Description
The DATK32 monoclonal antibody reacts with mouse LPAM-1 also known as integrin alpha 4 beta 7. The 130 kDa integrin β7 chain associates with the 150 kDa integrin α4 (CD49d) chain to form LPAM-1, a member of the Ig superfamily. LPAM-1 is expressed by peripheral lymphocytes, small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds VCAM-1 (CD106), MAdCAM-1, and fibronectin and facilitates lymphocyte adhesion and migration to the intestine and associated lymphoid tissues. The DATK32 antibody has been reported to block LPAM-1-mediated cell adhesion in vivo.
Reactivity
Mouse
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis. Duc D et al., 2019 Oct 8, Cell Rep
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Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization. Bemark M et al., 2016 Sep 6, Nat Commun
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Regulatory B cells are induced by gut microbiota-driven interleukin-1beta and interleukin-6 production. Rosser EC et al., 2014 Nov, Nat Med
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Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function. Sheridan BS et al., 2014 May 15, Immunity
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Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohns Disease. Lindebo Holm T et al., 2012, Int J Inflam
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