InVivoMAb anti-mouse/human/rat CCL2 (MCP-1)

Name: InVivoMAb anti-mouse/human/rat CCL2 (MCP-1)
SKU: BE0185_B56
Availability: BackOrder

BE0185

ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking

Product group Antibodies

ReactivityHuman, Mouse, Rat

Overview

Supplier
Bio X Cell
Product Name
InVivoMAb anti-mouse/human/rat CCL2 (MCP-1)
Delivery Days Customer
7
Applications
ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
2H5
Concentration
4-11 mg/ml
Estimated Purity
>95%
Host
Hamster
Isotype
IgG
Scientific Description
The 2H5 antibody reacts with mouse, human, and rat CCL2 also known as monocyte chemoattractant protein 1 (MCP-1). CCL2 is a 13 kDa chemokine that is produced mainly by monocytes/macrophages but is also expressed by endothelial, fibroblasts, epithelial, smooth muscle, mesangial, astrocytic, and microglial cells. It can be expressed constitutively or after induction by oxidative stress, cytokines, or growth factors. CCL2 regulates the migration and infiltration of monocytes, memory T lymphocytes, and NK cells and is implicated in the pathogeneses of several diseases characterized by monocytic infiltrates, such as multiple sclerosis, psoriasis, rheumatoid arthritis, and atherosclerosis. The 2H5 antibody has been shown to neutralize the biological effects of CCL2 in vivo.
Reactivity
Human, Mouse, Rat
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Hypoxia-inducible factor-dependent induction of myeloid-derived netrin-1 attenuates natural killer cell infiltration during endotoxin-induced lung injury. Berg NK et al., 2021 Apr, FASEB J
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CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin. Brunner PM et al., 2015 Jul, Exp Dermatol
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Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation. Singh M et al., 2014 Nov 1, J Immunol
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Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. Tominaga T et al., 2009 Nov, Invest Ophthalmol Vis Sci
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