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InVivoPlus anti-mouse IL-17A
BP0173
Overview
- SupplierBio X Cell
- Product NameInVivoPlus anti-mouse IL-17A
- Delivery Days Customer7
- ApplicationsNeutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID17F3
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-17A in vivo.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Faraco G et al., 2018 Feb, Nat NeurosciRead more
- Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance. Xiong H et al., 2016 Apr 21, CellRead more
- IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Coffelt SB et al., 2015 Jun 18, NatureRead more
- Control of murine cytomegalovirus infection by gammadelta T cells. Sell S et al., 2015 Feb, PLoS PathogRead more
- Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Naik S et al., 2015 Apr 2, NatureRead more
- Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis. Kulcsar KA et al., 2014 Nov 11, Proc Natl Acad Sci U S ARead more
- Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice. Khmaladze Ia et al., 2014 Sep 2, Proc Natl Acad Sci U S ARead more
- Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2. Xin L et al., 2014 Jul 22, Proc Natl Acad Sci U S ARead more
- Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice. Ermann J et al., 2014 Jun 24, Proc Natl Acad Sci U S ARead more
- TNF-alpha-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. Uddin MN et al., 2014 Feb 15, J ImmunolRead more
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