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ProductsBack/Ionomycin (free acid) [56092-81-0]
Chemical Structure
Chemical Structure
Chemical Structure

Ionomycin (free acid) [56092-81-0]

Research Use Only
AG-CN2-0416
AdipoGen Life Sciences
CAS Number56092-81-0
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight709
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ionomycin (free acid) [56092-81-0]
  • Delivery Days Customer
    10
  • CAS Number
    56092-81-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C41H72O9
  • Molecular Weight
    709
  • Scientific Description
    Antibiotic [1]. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators [2, 3]. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+ [3, 9]. Apoptosis inducer [4, 7]. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination [6]. Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA [5, 8]. ADAM10 agonist [10]. Potent inducer of shedding CXCL16 [10]. TREK-1 channels inhibitor [11]. PPARgamma ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes [12]. - Chemical. CAS: 56092-81-0. Formula: C41H72O9. MW: 709. Isolated from Streptomyces conglobatus. Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+. Apoptosis inducer. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination. Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA. ADAM10 agonist. Potent inducer of shedding CXCL16. TREK-1 channels inhibitor. PPARgamma ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes.
  • SMILES
    [H][C@@]1(CC[C@](C)(O1)[C@@H](C)O)[C@]1(C)CC[C@@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C\C[C@@H](C)C[C@@H](C)C(\O)=C\C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(O)=O)O1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Ionomycin, a new polyether antibiotic: W.C. Liu, et al.; J. Antibiot. 31, 815 (1978)
  • Characterization of ionomycin as a calcium ionophore: C. Liu & T.E. Hermann; J. Biol. Chem. 253, 5892 (1978)
  • Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria: R.F. Kauffman, et al.; J. Biol. Chem. 255, 2735 (1980)
  • Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes: D.M. Ojcius, et al.; Exp. Cell Res. 197, 43 (1991)
  • Contrasting effect of transforming growth factor type beta 1 (TGF-beta 1) on proliferation and interleukin-2 receptor expression in activated and rapidly cycling immature (CD3-CD4-CD8-) thymocytes: A. Dupuy d'Angeac, et al.; J. Cell. Physiol. 154, 44 (1993)
  • Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons: N. Takei & Y. Endo; Brain Res. 652, 65 (1994)
  • Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis: K.M. Aagaard-Tillery, et al.; J. Immunol. 155, 3297 (1995)
  • Flow cytometric analysis of intracellular IFN-gamma, IL-4 and IL-10 in CD3+4+ T-cells from rat spleen: E.M. Caraher, et al.; J. Immunol. Methods 244, 29 (2000)
  • The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin: S.A. Hamidinia, et al.; Biochemistry 43,15956 (2004)
  • Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin: F. Scholz, et al.; J. Invest. Dermatol. 127, 1444 (2007)