IRAK1 peptide

GeneTex

IRAK1 peptide

9

The peptide is used for blocking the activity of anti-IRAK (cat. no 238). Incubating the peptide with equal volume of antibody for 30 min at 37C usually completely blocks the activity of anti-IRAK in Western blotting.

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in the IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

-20°C

12352202