Western Blot analysis of Human fetal liver tissue and Mouse heart tissue,Human testis tissue using IRAK1BP1 Polyclonal Antibody at dilution of 1:475
Western Blot analysis of Human fetal liver tissue and Mouse heart tissue,Human testis tissue using IRAK1BP1 Polyclonal Antibody at dilution of 1:475
IRAK1BP1 Polyclonal Antibody
E-AB-10411
Product group Antibodies
Overview
- SupplierElabscience
- Product NameIRAK1BP1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA WB IHC
- CertificationResearch Use Only
- Concentration0.4mg/ml
- Scientific DescriptionSIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
- UNSPSC12352203