IRAK4-IN-22

MedChem Express

IRAK4-IN-22

10

Research Use Only

98.20

C28H28FN7O2

513.57

IRAK4-IN-22 (compound 18) is an orally active, potent and selective IRAK4 inhibitor with IC50 values of 3 and 17 nM for IRAK4 and TAK1, respectively. IRAK4-IN-21 effectively inhibits IL-23 production (IC50=0.10 microM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis[1].

O=C([C@H]1[C@@H](C2)C=C[C@@H]2[C@H]1NC3=NC(NC4=CC=CC(C(N5CCCC5)=O)=C4)=NC=C3C6=CC(F)=NC=C6)N

-20°C,2°C to 8°C

12352200