More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/IRF Reporter (Luc) - THP-1 Cell line

IRF Reporter (Luc) - THP-1 Cell line

Research Use Only
79858
BPS Bioscience
Product group (Cell) Culture
Price on request
Packing Size
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    BPS Bioscience
  • Product Name
    IRF Reporter (Luc) - THP-1 Cell line
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Scientific Description
    The Interferon Regulatory Factor (IRF) reporter (Luc)-THP-1 cell line is designed to study the activation and signaling of Cytosolic DNA Sensors (CDS) in human monocytic cell line THP-1. It contains a firefly luciferase gene driven by multimerized ISRE (Interferon Stimulated Response Element) located upstream of the minimal TATA promoter. The cGAS-STING pathway acts to detect cytosolic DNA and induce an immune response. Briefly, upon binding DNA, the protein cGAS (cyclic GMP-AMP Synthase) triggers reaction of GTP and ATP to form cGAMP. cGAMP binds to STING (Stimulator of Interferon Genes) which triggers phosphorylation of IRF3 via TBK1. IRF3 can then bind to interferon-stimulated responsive elements (ISRE) in the nucleus and leads to IFN-alpha/beta production. The IRF reporter (Luc)-THP-1 cell line is highly responsive to STING and CDS ligands.
  • Storage Instruction
    Liquid Nitrogen
  • UNSPSC
    41116155