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ProductsBack/Isoliquiritigenin [961-29-5]
Chemical Structure
Chemical Structure
Chemical Structure

Isoliquiritigenin [961-29-5]

Research Use Only
AG-CN2-0459
AdipoGen Life Sciences
CAS Number961-29-5
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight256.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Isoliquiritigenin [961-29-5]
  • Delivery Days Customer
    10
  • CAS Number
    961-29-5
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Hazard Information
    Warning
  • Molecular Formula
    C15H12O4
  • Molecular Weight
    256.3
  • Scientific Description
    Anticancer. Apoptosis inducer and cell proliferation inhibitor. Autophagy inducer. Anti-angiogenic. VEGF/VEGFR-2 signaling inhibitor. Antioxidant and antibacterial. AMPK-mediated GSK3beta inhibitor. Anti-inflammatory. Inhibits translocation and activation of NF-kappaB by blocking phosphorylation and subsequent degradation of IkappaBalpha. Downregulates TRIF-dependent signaling pathways of TLRs by inhibiting TBK1 kinase activity. Blocks LPS-induced TLR4/MD2 complex signaling. NLRP3 inflammasome activation inhibitor. Inhibits NLRP3-activated ASC oligomerization. Can block the NLRP3 inflammasome at both the priming step and the activation step. H(2) histamine receptor signaling inhibitor. Anti-diabetic. Antihyperglycemic. Aldose reductase inhibitor. Vasorelaxant. Soluble guanylyl cyclase activator. GABAA receptor positive allosteric modulator. Potent cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor. Shown to inhibit breast cancer stem cells through WIF1 demethylation. Shows outstanding matrix properties for MALDI-TOF-MS analysis of oligosaccharides. Antiviral Reduces lung inflammation Activator of Bone Morphogenetic Protein BMP signaling. - Chemical. CAS: 961-29-5. Formula: C15H12O4. MW: 256.3. Synthetic. Originally isolated from Glycyrriza sp. Anticancer. Apoptosis inducer and cell proliferation inhibitor. Autophagy inducer. Anti-angiogenic. VEGF/VEGFR-2 signaling inhibitor. Antioxidant and antibacterial. AMPK-mediated GSK3beta inhibitor. Anti-inflammatory. Inhibits translocation and activation of NF-kappaB by blocking phosphorylation and subsequent degradation of IkappaBalpha. Downregulates TRIF-dependent signaling pathways of TLRs by inhibiting TBK1 kinase activity. Blocks LPS-induced TLR4/MD2 complex signaling. NLRP3 inflammasome activation inhibitor. Inhibits NLRP3-activated ASC oligomerization. Can block the NLRP3 inflammasome at both the priming step and the activation step. H(2) histamine receptor signaling inhibitor. Anti-diabetic. Antihyperglycemic. Aldose reductase inhibitor. Vasorelaxant. Soluble guanylyl cyclase activator. GABAA receptor positive allosteric modulator. Potent cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor. Shown to inhibit breast cancer stem cells through WIF1 demethylation. Shows outstanding matrix properties for MALDI-TOF-MS analysis of oligosaccharides.
  • SMILES
    OC1=CC=C(\C=C\C(=O)C2=C(O)C=C(O)C=C2)C=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • The potent anti-tumor-promoting agent isoliquiritigenin: S. Yamamoto, et al.; Carcinogenesis 12, 317 (1991)
  • Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice: M. Tawata, et al.; Eur. J. Pharmacol. 212, 87 (1992)
  • Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta: S.M. Yu & S.C. Kuo; Br. J. Pharmacol. 114, 1587 (1995)
  • Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation: J. Vaja, et al.; Free Radic. Biol. Med. 23, 302 (1997)
  • Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells: Y.L. Hsu, et al.; Planta Med. 71, 130 (2005)
  • Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells: Y.L. Hsu, et al.; Life Sci. 77, 279 (2005)
  • Isoliquiritigenin selectively inhibits H(2) histamine receptor signalling: D.C. Kim, et al.; Mol. Pharmacol. 70, 493 (2006)
  • Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells: S. Kumar, et al.; Biochem. Pharmacol. 73, 1602 (2007)
  • AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress: S.H. Choi, et al.; Biochem. Pharmacol. 79, 1352 (2010)
  • Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1: S.J. Park & H.S. Youn; J. Agric. Food Chem. 58, 4701 (2010)