Ispronicline

MedChem Express

Ispronicline [252870-53-4]

10

252870-53-4

98.24

C14H22N2O

234.34

Ispronicline (TC-1734), an orally active, brain-selective alpha4beta2 nicotine acetylcholine receptor ( nAChR ) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the alpha4beta2 nAChR with high affinity ( K i =11 nM) and is highly selective to other nAChRs such as alpha7 nAChR and alpha3beta4 nAChR [1] [2] .

C[C@H](NC)C/C=C/C1=CC(OC(C)C)=CN=C1

-20°C,2°C to 8°C

12352200