Ivacaftor-d19

MedChem Express

Ivacaftor-d19 [1413431-22-7]

10

1413431-22-7

Research Use Only

C24H9D19N2O3

411.61

Ivacaftor-d 9 is a potent CFTR modulator and exhibits an EC 50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research [1] .

O=C(C1=CNC2=C(C=CC=C2)C1=O)NC3=CC(O)=C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])C([2H])=C3C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

-20°C,2°C to 8°C

12352200