Ivaltinostat formic
T63074
Overview
- SupplierTargetMol Chemicals
- Product NameIvaltinostat formic
- Delivery Days Customer10
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameIvaltinostat formic
- Molecular FormulaC25H35N3O6
- Molecular Weight473.56
- Scientific DescriptionIvaltinostat (CG-200745) formic is an orally active pan-HDAC inhibitor with an isohydroxamic acid component that binds zinc at the bottom of the catalytic pocket. Ivaltinostat formic inhibits the deacetylation of histone H3 and tubulin, promotes p53 accumulation, induces p53-dependent transactivation, and enhances MDM2 and p21 (Waf1/Cip1) protein expression. It increases the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU), induces apoptosis, and has antitumor effects.
- Shelf life instruction3 years
- Storage Instruction-20°C
- UNSPSC12352200