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ProductsBack/Ixazomib Citrate (MLN9708) Analogue [1201902-80-8]

Ixazomib Citrate (MLN9708) Analogue [1201902-80-8]

Research Use Only
S2181
Selleck Chemicals
Product group Chemicals
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Overview

  • Supplier
    Selleck Chemicals
  • Product Name
    Ixazomib Citrate (MLN9708) Analogue [1201902-80-8]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Scientific Description
    Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (bèta5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to bèta1 and little activity to bèta2. Ixazomib (MLN2238) induces autophagy. Phase 3.
  • UNSPSC
    12352200