Bio-Connect

JAK 3i

HY-100849
MedChem Express
Molecular Weight354.34
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    JAK 3i
  • Delivery Days Customer
    14
  • Molecular Formula
    C18H15FN4O3
  • Molecular Weight
    354.34
  • Scientific Description
    JAK3i is a highly selective JAK3 inhibitor ( IC 50 : 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research [1] .
  • SMILES
    CCOC(C1=CN=C2C1=C(C3=C(F)C=CC(NC(C=C)=O)=C3)NC=N2)=O
  • UNSPSC
    12352200