JAK 3i

MedChem Express

JAK 3i

14

Research Use Only

C18H15FN4O3

354.34

JAK3i is a highly selective JAK3 inhibitor ( IC 50 : 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research [1] .

CCOC(C1=CN=C2C1=C(C3=C(F)C=CC(NC(C=C)=O)=C3)NC=N2)=O

12352200