JAK3-IN-11
HY-146727
Molecular Weight401.46
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameJAK3-IN-11
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC23H23N5O2
- Molecular Weight401.46
- Scientific DescriptionJAK3-IN-11 (Compound 12), a potent, noncytotoxic, irreversible, orally active JAK3 inhibitor with IC50 value of 1.7 nM, has excellent selectivity (>588-fold compared to other JAK isoforms), covalently bind to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T cell proliferation, is a promising tool for study autoimmune diseases.
- SMILESC=CC(NC1=CC=C(C=C1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2)=O
- Storage InstructionSee Manual
- UNSPSC12352200