CgoaEWY7QZaEKNGxAAAAABxAT6o704.png
CgoaEWY7QZaEKNGxAAAAABxAT6o704.png
JAK3i [1918238-72-8]
T27650
Overview
- SupplierTargetMol Chemicals
- Product NameJAK3i [1918238-72-8]
- Delivery Days Customer9
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameJAK3i
- Molecular FormulaC18H15FN4O3
- Molecular Weight354.34
- Scientific DescriptionJAK3i is a selective covalent inhibitor of JAK3 kinase. JAK3i reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cell proliferation.
- Shelf life instruction3 years
- SMILESC(OCC)(=O)C=1C2=C(N=CN=C2NC1)C3=CC(NC(C=C)=O)=CC=C3F
- Storage Instruction-20°C
- UNSPSC12352200
References
- Dammeijer F, et al. Low-Dose JAK3 Inhibition Improves Antitumor T-Cell Immunity and Immunotherapy Efficacy. Mol Cancer Ther. 2022;21(9):1393-1405.Read more