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ProductsBack/Jak/Src Inhibitor 1 . hydrochloride [1332329-27-7]
Chemical Structure
Chemical Structure
Chemical Structure

Jak/Src Inhibitor 1 . hydrochloride [1332329-27-7]

Research Use Only
AG-CR1-3647
AdipoGen Life Sciences
CAS Number1332329-27-7
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight582.0 . 36.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Jak/Src Inhibitor 1 . hydrochloride [1332329-27-7]
  • Delivery Days Customer
    10
  • CAS Number
    1332329-27-7
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C28H23ClF3N7O2 . HCl
  • Molecular Weight
    582.0 . 36.5
  • Scientific Description
    Chemical. CAS: 1332329-27-7 (parent). Formula: C28H23ClF3N7O2 . HCl. MW: 582.0 . 36.5. Multi-kinase inhibitor with potent antiproliferative activity. Potent STAT3/5 inhibitor in vitro and in vivo. Combined inhibitor of pSTAT3 proteins such as JAK, SRC, ABL and class III/V receptor tyrosine kinases (RTK), including FLT3, c-KIT, CSF1-R, PDGFRs and VEGFRs, in nanomolar range. - Multi-kinase inhibitor with potent antiproliferative anti-migratory activities. Potent STAT3/5 inhibitor in vitro and in vivo. Combined inhibitor of key kinases phosphorylating STAT3 and STAT5 proteins such as JAK, SRC, ABL families of kinases, and class III/V receptor tyrosine kinases (RTK), including FLT3, c-KIT, CSF1-R, PDGFRs and VEGFRs, in nanomolar range.
  • SMILES
    O=C(NC)C(C=C1)=CC=C1NC2=NC=C3C(CCN(C4=CC(NC(C5=NC=CC(C(F)(F)F)=C5)=O)=CC=C4Cl)C3)=N2.Cl
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Debio 0617B inhibits growth of STAT3-driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases: M. Murone, et al.; Mol. Cancer Ther. 15, 2334 (2016)
  • The multi-kinase inhibitor Debio 0617B reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells: M. Murone, et al.; Mol. Cancer Ther. (Epub ahead of print) (2017)