JB170 [2705844-82-0]

TargetMol Chemicals

JB170 [2705844-82-0]

999

Chemical

Research Use Only

JB170

C48H44ClFN8O11

963.36

JB170, a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM), achieves its selectivity by linking Alisertib to the Cereblon-binding molecule Thalidomide. It demonstrates a strong preference for AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 microM). The mechanism of JB170 involves S-phase arrest, specifically through AURORA-A depletion, and it is notably effective in inhibiting the non-catalytic functions of AURORA-A kinase [1].

3 years

O=C(NCCOCCOCCNC(=O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(C=C4OC)NC=5N=CC6=C(N5)C=7C=CC(Cl)=CC7C(=NC6)C=8C(F)=CC=CC8OC

-20°C

12352200