JBJ-08-178-01

MedChem Express

JBJ-08-178-01

9

Research Use Only

C31H30N8O3

562.62

JBJ-08-178-01 is a mutant-selective tyrosine kinase inhibitor against human epidermal growth factor receptor 2 ( HER2 ) with an antitumoral activity. JBJ-08-178-01 reduces both the kinase activity and protein levels of HER2 by inducing proteasomal degradation of the receptor in lung cancer. JBJ-08-178-01 is promising for research of non-small-cell lung cancer [1] [2] [3] .

CC1=CC(NC2=C3C=C(NC(/C=C/CN(C)C)=O)C(OCC)=CC3=NC=C2C#N)=CC=C1OC4=CC5=NC=NN5C=C4

12352200