JDB175 [2635328-79-7]

TargetMol Chemicals

JDB175 [2635328-79-7]

16

Chemical

Research Use Only

JDB175

C26H21F3N4O2

478.47

JDB175, a selective BTK inhibitor with oral bioavailability, demonstrates excellent penetration through the blood-brain barrier. It exhibits potent activity against central nervous system lymphoma in a mouse model, with no apparent toxicity. JDB175 effectively suppresses human lymphoma cell proliferation by inhibiting the BTK signaling pathway, induces cell cycle arrest, and promotes apoptosis[1].

3 years

FC1=C2C(=NN(C2=CN=C1)C3=CC=C(OC4=C(F)C(F)=CC=C4)C=C3)[C@H]5CN(C(C=C)=O)CCC5

-20°C

12352200