JGB-1-155 [3011930-28-9]

TargetMol Chemicals

JGB-1-155 [3011930-28-9]

16

Research Use Only

C26H38N2O3

426.59

JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 microM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFalpha-induced reactive oxygen species (ROS) in HT-22 cells [1].

C(CN(C(=O)C1=CC=CO1)CC2=CC=C(N(C)C)C=C2)C3(C(C)C)CC(C)(C)OCC3

-20°C

12352200