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JH-II-127

JH-II-127

T7155
TargetMol Chemicals
CAS Number1700693-08-8
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Product group Chemicals
Molecular Weight416.86
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    JH-II-127
  • Delivery Days Customer
    4
  • CAS Number
    1700693-08-8
  • Category Supplier
    Chemical
  • Chemical Name
    JH-II-127
  • Molecular Formula
    C19H21ClN6O3
  • Molecular Weight
    416.86
  • Scientific Description
    JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),
  • Shelf life instruction
    3 years
  • SMILES
    N(C)C1=C2C(=NC(NC3=C(OC)C=C(C(=O)N4CCOCC4)C=C3)=N1)NC=C2Cl
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor[J]. ACS Medicinal Chemistry Letters, 2015, 6(5):584-589.
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