JH-XI-10-02 [2209085-22-1]

TargetMol Chemicals

JH-XI-10-02 [2209085-22-1]

44

2209085-22-1

Chemical

Research Use Only

JH-XI-10-02

C53H69N5O9

920.161

JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.

3 years

[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)N(C)C(=O)CCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1ccc2ccncc2c1

-20°C

12352200