JI069

MedChem Express

JI069

9

Research Use Only

C15H12Cl2N2O4S

387.24

JI069 is a novel JAK-STAT inhibitor that demonstrates potent activity in suppressing Th1, Th2, and Th17 differentiation while promoting iTreg differentiation. JI069 effectively inhibits STAT3 activation as well as the activation of other STATs, including STAT1, STAT5, and STAT6. JI069 has shown significant therapeutic potential in alleviating symptoms of collagen-induced arthritis in mice while inhibiting cytokine production from T cells and the phosphorylation of STAT3 in synovial cells.

O=C(C1=C(NC(COC(CC2=C(Cl)C=CC=C2Cl)=O)=O)SC=C1)N

12352200