JNJ-39758979

MedChem Express

JNJ-39758979 [1046447-90-8]

5

1046447-90-8

Research Use Only

99.71

C11H19N5

221.308

JNJ-39758979 is a selective, orally active, and high-affinity histamine H 4 receptor antagonist with K i s of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H 4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity [1] [2] .

NC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1

2°C to 8°C

12352200