JNK-IN-12

MedChem Express

JNK-IN-12

14

Research Use Only

C56H82N16O7

1091.35

JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor (IC50=66.3 nM), consisting of a mitochondrial-specific cell-penetrating peptide and a specific inhibitor of JNK, SP600125 (HY-12041). JNK-IN-12 doesnt inhibit nuclear JNK signaling, but does inhibit mitochondrial JNK phosphorylation. JNK-IN-12 helps to improve the Parkinsons disease (PD) both in vitro and in vivo[1].

O=C1C2=C(NCCNC(CCCC3=CN(CCCC(N[C@H](C(N[C@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CC4CCCCC4)=O)=O)CC5CCCCC5)=O)N=N3)=O)C=CC=C2C6=NNC7=C6C1=CC=C7

12352200