JNK2-IN-1

MedChem Express

JNK2-IN-1

14

Research Use Only

C30H26N4O5

522.55

JNK2-IN-1 (Compound J27) is a JNK2 inhibitor (Kds: 79.2 microM). JNK2-IN-1 has anti-inflammatory activity. JNK2-IN-1 decreases the release of TNF-alpha and IL-6 through inhibiting the activation of NF-kappaB/MAPK pathway. JNK2-IN-1 alleviates the symptoms of LPS-induced acute lung injury (ALI) and sepsis[1].

CC1=CC=C(C=C1)N2C(C=C(C(C(NC3=CC=C(OC4=C5C(C=C(C(OC)=C5)OC)=NC=C4)C=C3)=O)=N2)C)=O

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