JNK3 inhibitor-5

MedChem Express

JNK3 inhibitor-5

10

Research Use Only

C26H27Cl2N7O2

540.44

JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable[1].

NC(C1CC2=C(C1)N=C(C3=CC(Cl)=C(C=C3)Cl)N2C4=NC(N[C@@H]5CN(CCC5)C(C6CC6)=O)=NC=C4)=O

12352200