JNK3 inhibitor-8

MedChem Express

JNK3 inhibitor-8

10

Research Use Only

C32H30FN7O3

579.62

JNK3 inhibitor-8 is a potent, delective, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 21, 2203, >10000 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-8 shows significant neuroprotective effects. JNK3 inhibitor-8 has the potential for the research of Alzheimers disease (AD)[1].

O=C(N1C[C@@H](NC2=NC=CC(N3C4=C(N=C3C5=CC6=C(C=C5)C=CC=C6)C(F)=CC(OC(NC)=O)=C4)=N2)CCC1)C7CC7

12352200